Abstract

ENCISO-RAMIREZ, Mayra Alejandra; REYES-CASTILLO, Zyanya  and  VALDES-MIRAMONTES, Elia Herminia. Genetic variants in CD36: emerging role in oral fat perception and food preferences. Nutr. Hosp. [online]. 2023, vol.40, n.6, pp.1262-1269.  Epub Mar 04, 2024. ISSN 1699-5198.  https://dx.doi.org/10.20960/nh.04711.

CD36 is a receptor involved in physiologic, metabolic and pathologic processes. Due to its affinity for long-chain fatty acids, it has been postulated as a taste receptor of fatty taste. In this review, the emerging genetic evidence linking CD36 to oral fat perception is analyzed. A systematic literature search was conducted in PubMed, published articles from 2000 to 2022 were considered. Multiple studies have shown an association of some genetic variants in CD36 with fat foods preferences and it has been suggested that these variants can modify oral fat perception thresholds however the evidence is still heterogeneous; this can be explained by the genetic diversity of populations, the nutritional status and participant's characteristics, as well as other methodological aspects. Other factors involved in oral fat perception were and identified and discussed including the interaction with other flavors, hormones, and epigenetic factors. The conclusion is that the evidence supporting the role of CD36 as a dietary lipid receptor, the role of its genetic variants in fat acids oral perception thresholds and food preferences is intermediate level and more research is necessary in other populations with large number of participants as well as considering the interaction between different hormones and the expression of CD36.

Keywords : CD36; SNP; Fatty taste; Food preferences; Thresholds.

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