Abstract

CABARCOS ORTIZ DE BARRON, A. et al. Correlation between mantoux and tuberculin´s fraction from delayed hypersensitivity skin test, in a cohort from HIV-1 positive patients, in function of immunodeficiency level, and active tuberculosis incidence. An. Med. Interna (Madrid) [online]. 2000, vol.17, n.12, pp.12-20. ISSN 0212-7199.

Objetives: The aim of this work was to assess cellular immunity using the multitest CMI and relate its results with lymphocyte CD4 counts, and the risk to developed active tuberculosis if the multitest´s tuberculosis pápula was positive. Methods: prospective longitudinal follow-up of 342 IDU patients, 210 infected with HIV-1 and seronegative 132 patients. The cohort study was 165 IDU HIV-1 positive patients (128 men, 37 female). Ages was 18 to 45 years. Study time were 25 months (8-25). Tuberculin skin tests and multitest IMC were performed at baseline and each three months, and screening from active tuberculosis were performed all study when necesary was considerated. Results: Actived tuberculosis developed in 9.25 cases per one hundred persons and year from follow-up in the ranges with better immmunologic status (Score from PHR >10 mm). There are an significative corelation between tuberculosis skin test diameter and PHR tuberculin fraction papula Conclusions: PHR performed with Multitest IMC is an useful test to evaluate celular immune system, and HIV-1 positive patients with anergy in this test or positive tuberculine fraction must be considerated to isoniazid (9 months) prophylaxis.

Keywords : Tuberculosis; Mantoux; PPD; Tuberculin skin test, multitest; CD4 lymphocite count; Delayed hypersensitivity.

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