Abstract

ZAMARRON, C.; CAMPO, F. del; PAREDES, C.  and  RODRIGUEZ SUAREZ, J.R.. Study of diffusion capacity of CO in two differents clinical situations: bronchial asthma and diabetes mellitus. An. Med. Interna (Madrid) [online]. 2001, vol.18, n.5, pp.15-22. ISSN 0212-7199.

Objective: The aim of our work has been the study and comparison of diffusion capacity of CO (DLCO) in two differents clinical situations: bronchial asthma and diabetes mellitus. Method: We have studied 16control subjects, 38 patients with bronchial asthma and 65 patients with diabetes mellitus. We performed CO pulmonary diffusion tests by single breath method to determine two components: membrane diffusion factor (Dm) and pulmonary capillary blood volume (Vc). Results: We have found a positive correlation of FEV1 with Dm. The bronchial asthma group had a lower FEV1 and FEF25-75% and an increase in DLCO, Dm and Vc, with respect to the control group. The diabetes mellitus group presented a decrease in CVF, FEV1, DLCO and Vc, with respect to the control group. The bronchial asthma group showed a lower ratio of Dm/Vc than the control and diabetes groups. Conclusions: The bronchial asthma patients have an increase in CO pulmonary diffusion, membrane diffusion factor and pulmonary capillary volume. However, the diabetes mellitus patients present a decrease in CO pulmonary diffusion mainly due to pulmonary capillary volume

Keywords : Bronchial asthma; Diabetes mellitus; Pulmonary diffusion tests; Pulmonary capillary blood volume.

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