Abstract

ALLER REYERO, Mª A. et al. Evolutive types of prehepatic portal hypertension of the rat. An. Med. Interna (Madrid) [online]. 2002, vol.19, n.7, pp.23-33. ISSN 0212-7199.

Objective: A long-term study of the prehepatic portal hypertension model by triple stenosing ligation of the portal vein in the rat.  Method: A cluster analysis of the animals in the different evolutive stages of portal hypertension (1 1/2, 6, 12 and 14 months) has been carried out. This analysis has made it possible to identify three homogeneous groups (A, B and C) in relationship to the liver weight.  Results: The animals with liver atrophy (group C) show a decrease of body, splenic and testicular weights as well as a higher development of the portosystemic collateral circulation in relation to the A and B groups.  Conclusion: The percentage of animals belonging to the group C decrease progressively during the evolution of portal hypertension and those animals corresponding to the group A, in which is superior the liver weight, increase, while the B group does not change. 

Keywords : Portal hypertension; Rat; Liver.

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