Abstract

BOJANICH, A et al. Effect of polymers on the levels of lgAs anti Streptococcus mutans and the production of dextran of autothonous Streptococcus mutans(study in and in vivo). Av Odontoestomatol [online]. 2003, vol.19, n.5, pp.225-232. ISSN 2340-3152.

Effect of High Molecular Weight Quitosan (HMWQ) (0.25-0.50 g% P/V, NaOH 1M) and Sodium Alginate (Na-Al) (0.10-0.50 g% P/ V. CaCI₂ 1 M, was evaluated on the levels of IgAs anti Streptococcus mutans and the production of dextran. It was studied in saliva (in vitro) the effect of the polymers to 5', 8h and 24 h and in saliva from ten healthy subjects (study in vivo,) to 0, 1 and 3 h after the execution of a mouth rinse with polymers. The levels of IgAs anti St mutans were determined by ELlSA, they did not reveal statistically significant differences with regard to the control (p=0.05). The dextran production was determined at different concentrations of polymers by means of espectrofotometria (λ=520), using a suspension from 1 to 5.108 UFC ml of St mutans in sucrose broth 8,5%. The results showed significant reduction, to the formation of dextran with respect to the control (p<0.05), being for 32% to HMWQ 0.25 g% PN and 66,8% for HMWQ 0.50 g% P/V, while for Na-Al 0.10 g% PN was 30% and Na-Al 0.50 g% P V was the 32%. It is concluded that QAPM and Al- Na, with regard to their characteristic physical and chemistry that permit to form hydrogen bond Iike, and polymeric chains that confer sufficient elasticity to agree to the different structures of the oral cavity, offer expectations for the therapeutic investigation of new formulations of deontological application.

Keywords : Hight molecular chitosan; Sodium Alginate; IgAs anti-Streptococcus mutans; Dextran; Streptococcus mutans.

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