Abstract

HERNANDEZ GONZALEZ, D.; MENDEZ SILVA, J.  and  DIAZ CABALLERO, A.. Genotoxic effect of composites resins in dentistry: a review. Av Odontoestomatol [online]. 2014, vol.30, n.1, pp.29-38. ISSN 2340-3152.

Objective: To examine the available scientific evidence about the genotoxicity caused by monomers released from dental composite resins. Materials and methods: We carried out a comprehensive electronic search of studies related to the genotoxicity of composite resins or dental monomers using the databases PubMed, OvidSP, EBSCOhost, and SciVerseSpringerLink. We reviewed a total of 115 articles and 36 were selected from controlled clinical studies, animal studies and in vitro tests. Conclusions: Exposure to residual monomers released from composites, causes great concern about studies that warn their genotoxic potential. The main mechanism is attributed to oxidative stress is generated by increasing concentrations of free radicals and decreased levels of Glutathione redox agent responsible for the cell balance. These changes lead to the activation of multiple pathways of apoptosis and delays in G1 and G2 phases of the cell cycle.

Keywords : Genotoxicity tests; micronucleus test; comet assay; bisphenol A-glycidyl methacrylate; composites resins.

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