Abstract

MADERA ANAYA, M.V.; MONERIZ PRETELL, C.E.  and  SUAREZ CAUSADO, A.. Molecular implications of transforming growth factor beta (TGF-β) signaling pathway in the development of cleft lip and palate. Av Odontoestomatol [online]. 2016, vol.32, n.5, pp.251-258. ISSN 2340-3152.

Cleft lip and palate are generated by the lack of fusion of the tissues of the lip or palate during early fetal development, these are among the most common birth defects caused by abnormal facial development during gestation. The etiology of these cracks is not fully elucidated, however attempts to explain by means of multifactorial threshold model, considering that is the product of the interaction of endogenous and exogenous factors, endogenous alterations have been reported in TGF-β signaling, which is involved in embryonic development, cell differentiation and in the regulation of development of the palate. In this review, the recent advances implications of the molecular signaling pathway TGF-β in the development of cleft lip and palate shown.

Keywords : Development palate; cleft lip and palate; TGF-β; cell signaling pathways.

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