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Gaceta Sanitaria
Print version ISSN 0213-9111
Abstract
VEGA, Tomás et al. Genetic, environmental and life-style factors associated with longevity. Protocol and response of the LONGECYL Study. Gac Sanit [online]. 2022, vol.36, n.3, pp.260-264. Epub Sep 30, 2022. ISSN 0213-9111. https://dx.doi.org/10.1016/j.gaceta.2022.01.005.
Objective:
To describe the objectives, the methodological approach, the response rate of the Genetic, Environmental and Life-style Factors Study in Castilla y León (Spain).
Method:
The Health Sentinel Network studied a sample of long-lived individuals aged 95 or more (LLI). The study included biological samples processed with the Global Screening Array v3.0 that contains a total of 730,059 markers. Written consent was obtained before the examination.
Conclusions:
The LLI contacted were 944, and 760 were completed studied. The 87.4% of LLI were born in Castile and Leon and only 1% were non-native of Spain. Severe cognitive impairment was declared in 8.1% of men and 19.2% of women. Genotyping was performed in 739 LLI, the 78.3% of the contacted sample. Family doctors and nurses achieve high participation in population-based studies. DNA samples were taken from 94% of fully studied LLI, and 100% of these samples where successfully genotyped.
Keywords : Longevity; Epidemiology; Human genetics; Environment; Lifestyle.