Abstract

SANDOVAL, HP et al. Diffuse lamellar keratitis: prophylactic treatment with ketorolac tromethamine 0.5% in an animal model. Arch Soc Esp Oftalmol [online]. 2002, vol.77, n.11, pp.589-595. ISSN 0365-6691.

Purpose: The objective of this study is to evaluate the use of a topical non-steroidal anti-inflammatory drug in the treatment of induced diffuse lamellar keratitis (DLK) in an animal model. Materials and Methods: A corneal flap was created in 40 eyes of 20 Dutch-belted rabbits using the ASC microkeratome. The interface was inoculated with either Pseudomonas Aeruginosa Lipopolysaccharide (LPS) endotoxin or Ultra Palmolive® liquid dish washer. The rabbits were divided in two groups: Group I (n=20) treated with ketorolac tromethamine ophthalmic solution 0.5% 4 times a day and the group II (n=20) used as control. The rabbits were examined at the slit lamp at day 1, 3, 5 and 7 postoperatively. DLK was graded from I-IV. Results: At the end of the study 31 eyes were available for evaluation. 28 eyes (90%) developed DLK: 86% of the treated group and 94% of the control group during the follow-up. The treated group showed a lower rate of DLK as well as a lower severity. However, no statistically significant difference was found when comparing both groups (P > 0.05). Conclusion: Pseudomonas aeruginosa LPS endotoxin and Palmolive® Ultra can induce DLK in rabbit eyes. The postoperative prophylactic treatment with a topical non-steroidal anti-inflammatory drug showed a tendency towards a lower DLK rate as well as the severity of the disease.

Keywords : Diffuse lamellar keratitis; laser in situ keratomileusis; treatment; etiology.