Abstract

HERNANDEZ-DA MOTA, S.E.; CHACON-LARA, A.  and  HERNANDEZ-VAZQUEZ, E.. Use of triamcinolone and bevacizumab in 25G phaco-vitrectomy surgery for the treatment of cataract and diabetic macular edema. Arch Soc Esp Oftalmol [online]. 2008, vol.83, n.5, pp.293-299. ISSN 0365-6691.

Objective: To evaluate the safety and efficacy of combined phacoemulsification and triamcinolone-assisted vitrectomy with intravitreal injection of bevacizumab in patients with cataract and diffuse diabetic macular edema. Methods: In this prospective, non randomized, interventional case series we included 13 eyes of 13 patients with posterior subcapsular cataracts and diffuse macular edema who underwent phacoemulsification, 25G triamcinolone-assisted vitrectomy, endophotocoagulation and had a bevacizumab injection at the end of the procedure. The follow-up consisted of basal best corrected visual acuity, fluorescein angiography, and optical coherent tomography performed at 2 weeks, one, three and six months post-operatively. Results: An improvement in the best corrected visual acuity of at least two lines was seen in 10 of the 13 patients. The basal average central macular thickness initially was 358.23 µ (SD 50 µ) while at the end of follow-up was 216.6 µ (SD 23.2 µ). Conclusion: This combined surgical and pharmacological treatment resulted in an improvement of central macular thickness and non-progression of diabetic retinopathy in the six month follow-up period. Larger comparative studies are necessary to establish the real impact of this therapeutic approach.

Keywords : Cataract; phacoemulsification; vitrectomy; triamcinolone; bevacizumab.

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