Abstract

CAPELLA, M.J.; ALVAREZ DE TOLEDO, J.  and  PAZ, M.F. de la. Limbal stem cell deficiency following multiple intravitreal injections. Arch Soc Esp Oftalmol [online]. 2011, vol.86, n.3, pp.89-92. ISSN 0365-6691.

Case report: A 68 year-old male with idiopathic choroidal polypoidal vasculopathy received seven intravitreal injections of bevacizumab in the supero-nasal quadrant. He later developed a localized limbal stem cell deficiency which required limbal transplantation from the same eye. Two months after surgery, a slight improvement of visual acuity was noted, along with an intact ocular surface, clear cornea and decreased inflammation. Discussion: Repeated surgical trauma on the limbus and surrounding areas may damage the limbal stem cells, giving rise to a corneal epitheliopathy due to iatrogenic limbal deficiency. Repeated intravitreal injections may be considered as one of the possible causes.

Keywords : Iatrogenic limbal stem cell deficiency; Intravitreal injections; Epitheliopathy; Limbal transplantation.

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