Abstract

ALBERT, M.; BELTRAN, E.  and  MARTINEZ-COSTA, L.. Rituximab in rheumatoid arthritis-associated peripheral ulcerative keratitis. Arch Soc Esp Oftalmol [online]. 2011, vol.86, n.4, pp.118-120. ISSN 0365-6691.

Clinical case: We report two cases of patients affected by longstanding rheumatoid arthritis who developed a severe form of peripheral ulcerative keratitis (PUK). Neither of them had an optimal biological and clinical control of their systemic illness despite being treated with several disease-modifying antirheumatic drugs (DMARDs) and biologic therapy. High-dose systemic corticosteroids were given to treat the PUK without any success. Rituximab resulted in a favourable response with resolution of the corneal lesions and optimal control of their systemic illness. Discussion: Rituximab may be an additional tool to arrest progressive rheumatoid arthritis-associated PUK that is refractory to other drugs.

Keywords : Rituximab; Peripheral ulcerative keratitis; Rheumatoid arthritis.

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