Abstract

RODRIGUEZ-GIL, R.; GIL-HERNANDEZ, M.A.  and  AFONSO-RODRIGUEZ, A.. Macular hole and Alport's syndrome. Arch Soc Esp Oftalmol [online]. 2012, vol.87, n.7, pp.220-224. ISSN 0365-6691.  https://dx.doi.org/10.1016/j.oftal.2011.10.011.

Case report: We present the clinical cases of two male patients of 38 and 39 years, diagnosed with Alport's syndrome, who suffered a bilateral macular hole and a giant unilateral macular hole with retinal thinning in the other eye, respectively. Discussion: Alport's syndrome is a genetic disorder characterised by mutation of genes encoding type IV collagen, the main component of the internal limiting membrane, a structure identified in basal membrane of the retinal pigment epithelium-Brüch's membrane complex. This alteration can influence the predisposition to macular holes.

Keywords : Alport; Macular hole; Optical coherence tomography.

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