Abstract

CRUZ-SANCHEZ, M.D.  and  GOMEZ-DIAZ., O.. Systematic review: stem cells derived from adipose tissue, utility in facial lipoatrophy. Cir. plást. iberolatinoam. [online]. 2014, vol.40, n.2, pp.141-148. ISSN 1989-2055.  https://dx.doi.org/10.4321/S0376-78922014000200003.

The objective of this systematic review is to determine if the lipografts enriched with stem cells derived from adipose tissue are superior to the conventional fatty tissue grafts in the treatment of facial lipoatrophy. A systematic search was performed for publications in the databases: MEDLINE, SCOPUS, OVID SP, SCIELO and EMBASE. An evaluation was subsequently conducted based on current criteria of evidence-based medicine of the publications found by two independent reviewers and discrepancies in the analysis were resolved by agreement. The inclusion criteria were: randomized clinical trials, clinical series and case reports in humans; the reports in animals were excluded. We found 6 publications that meet the criteria previously mentioned. Between these, 2 randomized controlled clinical trials reported the superiority of the lipografts enriched with stem cells derived from adipose tissue in the treatment of facial lipoatrophy in terms of resistance to the reabsorption (volume preservation) and less need for new lipografts when compared with the conventional lipografts. We conclude that there are publications with good levels of evidence to suggest that the lipografts enriched with stem cells derived from adipose tissue are better than the conventional lipografts in the treatment of facial lipoatrophy. However, these are studies of recent publication and it is still necessary to have long-term follow-ups and with a greater number of patients to improve the already good levels of evidence available.

Keywords : Facial atrophy; Facial lipoatrophy; Facial hemiatrophy; Lipografts; Stem cells; Enriched lipografts; Scientific evidence.

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