Abstract

BOLADO-GUTIERREZ, Pedro et al. Malignant glomus tumor: a case report and review of the literature. Cir. plást. iberolatinoam. [online]. 2017, vol.43, n.2, pp.187-192. ISSN 1989-2055.

Malignant glomus tumors are rare malignancies of the mioarterial glomus body. We report a case of a malignant glomus tumor located in the right hand of a 72 years old patient. Magnetic resonance imaging identified a soft tissue tumor of the second finger, with deeper areas in contact with the flexor tendons, the first dorsal interosseous muscle and underlying bones. The extension study showed no macroscopic malignant disease. Histologically the tumor had a plexiform architecture. Tumor cells were in close relationship with small vessels, sometimes with positive PAS staining, had a fusiform and focally epithelioid morphology with moderate atypia and a mitotic rate of 4 mitosis in 10 high magnification fields, without a typical mitosis and tumor necrosis. Diffuse positivity staining for vimentin and actins mooth muscle was observed immunohistochemically, with cell-to-cell labelty for IV collagen and negative for CD34, caldesmon, desmin, keratins and S100. Wide excision with negative margins was performed and adjuvant radiotherapy was administered on hand, with no evidence of tumor recurrence after 9 months follow up. Additionally, a review of the literature of malignant glomus tumors located in the upper limb, and the differential diagnosis of this type of tumors located in the skin and subcutaneous tissue were presented.

Keywords : Malignant glomus tumor; Upper limb; Immunohistochemistry.

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