Abstract

GUARCH, R. et al. Metástasis ovárica de melanona maligno de tumor primario de origen desconocido. Oncología (Barc.) [online]. 2004, vol.27, n.3, pp.45-48. ISSN 0378-4835.

The capacity of malignant melanoma to develop a variety of histologic appearances, including those of various types of sarcomas, is well known. Malignant melanoma metastases to the ovary presented as a primary ovarian tumor are exceptional. We report an unusual case of unilateral ovarian metastatic malignant melanoma without clinical evidence of primary lesion. The clinical history and the pathological differential diagnosis are discussed. The patient presented an enlarged right ovary (12 cm) and a mesentery node (2 cm), both of them with a lobulated surface. Some areas, particularly in the ovary, showed tumor cells of epithelioid appearance with a striking peritheliomatous growth pattern. The mesentery node was completely different, showing a predominantly spindle-cell shaped aspect reminiscent of a malignant peripheral nerve sheath tumor, including geographic necrosis areas. The neoplastic cells stained positively with HMB-45, vimentin, actin and S-100 (diffusely). The distribution of the tumor node, the combination of the cell pattern and the immunohistochemical profile were consistent with a metastatic melanoma.

Keywords : Malignant melanoma; Ovary; Metastases.

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