Abstract

LOPEZ-MUNIZ, A.; GUTIERREZ, J. C.; GARCIA-FERNANDEZ, C.  and  HERRERO, A.. The prognostic importance of cell proliferation and angiogenesis tumor markers in oligodendroglioma. Oncología (Barc.) [online]. 2004, vol.27, n.5, pp.27-34. ISSN 0378-4835.

PURPOSE: The clinical behavior of oligodendroglioma (ODG) is unpredictable using clinical and histological criteria. The present tumor markers related to cell cycle regulation and angiogenesis might improve the possibility of predicting the clinical course of ODG. The aim of this study is the quantification of ki67 and CD34 expression in oligodendrogliomas and its correlation with histological grade and survival. MATERIAL AND METHODS: We studied 25 ODG. The ki67 and CD34 immunoexpression was determined by immunohistochemical techniques. Later, the quantitative study was carried out with a Qwin system image analysis program. Finally, ki67 and CD34 expression was quantified and a statistical analysis of the results was performed. RESULTS: The number of ki67 positive nuclei correlated with the malignancy of the lesion, and with the overall survival. Contrarily, the number of CD34-positive microvessels of OGD showed no significant correlation with neither histological grade nor survival. CONCLUSIONS: The obtained results suggest that ki67, as shown here by the number of immunomarked nuclei, is an important diagnostic indicator, and can be used as a poor prognostic parameter of OGD. On the contrary, angiogenesis, considered here by the CD-34-positive microvessels, is not a prognostic indicator of ODG.

Keywords : Oligodendroglioma; Angiogenesis; Cell proliferation; Ki67 antigen; CD34 antigen.

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