Abstract

AREVALO, F.; ARIAS STELLA, C.  and  MONGE, E.. Immunoexpression of p53 and cyclic D1 in adenomas of the gallbladder. Rev. esp. enferm. dig. [online]. 2007, vol.99, n.12, pp.694-697. ISSN 1130-0108.

Introduction: gallbladder adenomas are infrequent neoplasms whose relation to adenocarcinoma is not well understood. It has been suggested that adenomas and adenocarcinomas follow different molecular pathways. Material and methods: this is a comparative, cross-sectional study in which we compared p53 and D1 cyclin expression in adenomas and adenocarcinomas of the gallbladder. Results: we included 12 cases in each group. Expression of p53 occurred in 83.3% of adenocarcinomas and in 16.6% of adenomas (p = 0.003). D1 cyclin was expressed in a similar number of adenomas and adenocarcinomas. Conclusion: our results support the hypothesis that p53 is an important step in the pathogenesis of adenocarcinomas but not of adenomas of the gallbladder. D1 cyclin is apparently a common pathway involved in the genesis of both tumors.

Keywords : Gallbladder adenoma; Gallbladder adenocarcinoma; p53; Cyclin D1.

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