Abstract

PADILLO, F. J et al. Alteration of the renal regulatory hormonal pattern during experimental obstructive jaundice. Rev. esp. enferm. dig. [online]. 2009, vol.101, n.6, pp.408-412. ISSN 1130-0108.

Objective: the alteration of hormones regulating sodium and water status is related to renal failure in obstructive jaundice (OJ). Experimental design: OJ was induced by common bile duct ligation. Samples were obtained from the control (SO) and OJ groups at 24 and 72 hours, and at 7 days. Different parameters related to biliary obstruction, liver and renal injury, and vasoactive mediators such as renin, aldosterone, endothelin-1 (ET-1) and prostaglandin E2 (PGE₂) were studied. Results: bile duct ligation caused an increase in total bilirubin (p < 0.001) and alkaline phosphatase (AP) (p < 0.001). The SO and OJ groups had the same values for diuresis, renin, and creatinine clearance at 24 h. However, animals with OJ had a lower sodium concentration in urine than SO animals (p < 0.01), as well as an increase in aldosterone levels (p < 0.03). ANP levels were moderately increased during OJ but did not reach statistical significance when compared to the SO group. In contrast, OJ animals showed a rise in serum ET-1 concentration (p < 0.001) and increased PGE₂ in urine (p < 0.001). Conclusions: biliary obstruction induced an increase in ET-1 release and PGE₂ urine excretion. These hormones might play a role during the renal complications associated with renal disturbances that occur during OJ.

Keywords : Aldosterone; Creatinine; Endothelin-1; Obstructive jaundice; Renal dysfunction; Renin.

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