Abstract

BUSTO-BEA, Victoria et al. Collagenous sprue: Don't forget connective tissue in chronic diarrhea evaluation. Rev. esp. enferm. dig. [online]. 2013, vol.105, n.3, pp.171-174. ISSN 1130-0108.  https://dx.doi.org/10.4321/S1130-01082013000300010.

Collagenous sprue is a rare disease of the small bowel characterized by mucosal atrophy and excessive subepithelial collagen deposition. The etiology remains unclear and the diagnosis is based upon patient's clinical picture and anatomopathological findings. Clinically, collagenous sprue is characterized by persistent diarrhoea, severe malabsorption, multiple nutrient deficiencies and progressive weight loss. Differential diagnosis includes celiac disease, which is mandatory to rule out because of their frequent association. Gluten-free diet is the first therapeutic step, but it usually is not effective. However, recent studies show high success rates with immunomodulators, mainly corticosteroids. We report the case of a patient presenting with chronic diarrhea and severe malabsorption who was diagnosed with collagenous sprue, with no response to gluten free diet, but with excellent response to budesonida.

Keywords : Collagenous sprue; Chronic diarrhea; Celiac disease; Subepithelial fibrosis; Small bowel.

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