Abstract

MARTINEZ, Juan et al. Study of the expression of cathepsins in histological material from pancreatic lesions. Rev. esp. enferm. dig. [online]. 2016, vol.108, n.12, pp.780-784. ISSN 1130-0108.  https://dx.doi.org/10.17235/reed.2016.3749/2015.

Background and aims: To assess the expression levels of cathepsins in malignant and premalignant lesions. Methods: We retrospectively included patients who underwent pancreatic surgery on pancreatic solid or cystic masses. The expression of cathepsin H, L, B and S was determined in both types of samples. Lesions were divided into three categories: malignant (pancreatic adenocarcinoma and malignant mucinous neoplasms), premalignant (mucinous neoplasms) and benign (other lesions). Results: Thirty-one surgical resection samples were studied. The expression of cathepsins was significantly higher in malignant lesions than in premalignant and benign lesions (H 75%, 27%, 37% p = 0.05; L 92%, 36%, 37% p = 0.011; B 83%, 36%, 62% p = 0.069; S 92%, 36%, 25% p = 0.004, respectively). Conclusions: Cathepsins are overexpressed in histological samples of malignant lesions compared to premalignant and benign lesions. However, the expression of cathepsins is similar in both premalignant and benign lesions.

Keywords : Cathepsins; Pancreatic adenocarcinoma; Pancreatic mucinous neoplasms.

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