Abstract

RODRIGUES LAUREANO FILHO, J.; ALLAIS, M.; EDWARD MAURETTE, P.  and  ALBERGARIA BARBOSA, J.R.. A comparative study on the use of demineralized bone matrix of human origin and polyurethane derived from castor oil in bone regeneration processes: A histometric study on rabbit calvaria. Rev Esp Cirug Oral y Maxilofac [online]. 2007, vol.29, n.4, pp.250-259. ISSN 2173-9161.

Objective. The present study was aimed at carrying out a histological and histometric analysis on the effect of human demineralized bone matrix and a polyurethane resin, derived of the castor bean oil, on the bone regeneration process. Design: For this, 24 rabbits were used and in each calvarium two surgical bone defect were prepared, one on the right side and another on the left side of the parietal suture. The animals were divided into two groups. In group I the experimental defect (right side) was filled with polyurethane derived from oil of the castor oil plant, while in group II the experimental cavity was filled with demineralized bone matrix of human origin. The control cavities were just filled with the blood of the animal. The animals were sacrificed in the postoperative period at 04, 07 and 15 weeks. Results. The statistical analysis, which was based on the data of the histometric study, showed larger bone neoformation in groups I and II in relation to the control groups, and there were no statistical differences when the experimental groups were compared. Conclusions. The use of polyurethane resin implants and demineralized human bone matrix helped and optimized the regeneration process when compared with natural bone regeneration, and similar behavior was obtained without statistical differences in both materials.

Keywords : Bone matrix; Bone regeneration; Polyurethane resin implant.

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