Abstract

CARIBE, R. A.; CHAVES, G. R.; POCOGNONI, J. D.  and  SOUZA, I. A.. Potential drug interactions in patients with sepsis admitted to the intensive care unit. Farm Hosp. [online]. 2013, vol.37, n.5, pp.383-387. ISSN 2171-8695.  https://dx.doi.org/10.7399/FH.2013.37.5.534.

Objective: To analyze, detect and classify potential drug interactions in patients with sepsis admitted to the intensive care unit. Methods: This prospective observational cohort study of septic patients was conducted between April 2010 and August 2011. Data collection included demographic characteristics, clinical features, and analysis of pharmacotherapy. Results: Of 86 patients, 80% had potential drug interactions, with a mean of 1.84 ± 1.09 interaction per patient. Regarding the classification of drug interactions, 64.2% had a pharmacodynamic profile, 60% were of major severity, 53.3% had a rapid onset of action, and 53.8% had good documentation. The prevalence of interactions was associated with age, number of drugs prescribed, and length of stay in the intensive care unit (p < 0.001). Conclusion: This study showed that drug interactions represent an important clinical concern in septic patients admitted to intensive care units.

Keywords : Drug interactions; sepsis; Intensive Care Units.

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