Abstract

GARCIA-MUNOZ, C. et al. Lapatinib plus transtuzumab for HER-2 positive metastatic breast cancer: experience of use. Farm Hosp. [online]. 2014, vol.38, n.2, pp.130-134. ISSN 2171-8695.  https://dx.doi.org/10.7399/FH.2014.38.2.1107.

Objective: To describe the outcomes produced by concomitant use of HER2-receptor inhibitors Lapatinib and Trastuzumab for the treatment of HER 2-positive metastatic breast cancer. Method: Retrospective observational study. Patients treated with Trastuzumab and Lapatinib between January of 2010 and May of 2012 were selected. Demographical and clinical data were gathered. Results: 23 patients with metastatic breast cancer (mean age 59.3 ± 13.3 years) were included. All of them had received an average of 5 treatment lines with at least one of them including Trastuzumab. The median progression-free survival rate with combined Lapatinib + Trastuzumab, with or without associated chemotherapy was 7 months (95% CI: 2.78-11.21) and 3 months for the patients only receiving Lapatinib and Trastuzumab. Seven patients experienced adverse events and in four patients the treatment was stopped due to toxicity. Conclusions: The treatment with HER2-receptor inhibitors in our patients resulted in progression-free survival rates similar to those published in clinical trials with patients receiving Lapatinib + Trastuzumab not combined with any other anticancer therapy, with good treatment tolerability.

Keywords : Lapatinib; Trastuzumab; Metastatic breast cancer; HERZ receptor.

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