Abstract

GARCIA LAGUNAR, María Henar et al. Experience of off-label use of Eltrombopag in the treatment of thrombocytopenia associated with solid tumors. Farm Hosp. [online]. 2015, vol.39, n.3, pp.157-160. ISSN 2171-8695.  https://dx.doi.org/10.7399/fh.2015.39.3.8580.

Purpose: To describe the results of the off-label use of eltrombopag in patients with solid tumors and thrombocytopenia that limits chemotherapy. Methods: Retrospective observational study including all patients with solid tumors who were treated with eltrombopag for thrombocytopenia during the chemotherapy treatment between January 2012 and December 2014. Results: Six patients, with solid tumors and thrombocytopenia that limits chemotherapy treatment, received eltrombopag during the study and it was observed a decrease in the delay of chemotherapy cycles (4.83 ± 4.79 delayed cycles before starting eltrombopag vs 2.50 ± 4.32 delayed cycles during the treatment with eltrombopag, p=0.492) and an increase in the percentage of administrated dosage (89.29 ± 13.36% vs 91.43 ± 10.69%, p=0.682). Also, there was an increase in platelet nadir (55.29 ± 16.45x10⁹/L vs 76.14 ± 36.38x10⁹/L, p=0.248) without platelet transfusion support in any patient during treatment with eltrombopag. Conclusions: eltrombopag has resulted to be an alternative in the treatment of patients with thrombocytopenia that limits chemotherapy, clinical trials with more number or patients are needed to confirm these results.

Keywords : Eltrombopag; Thrombocytopenia; Chemotherapy; Solid tumors.

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