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Farmacia Hospitalaria
On-line version ISSN 2171-8695Print version ISSN 1130-6343
Abstract
ESTAN-CEREZO, Gabriel et al. Chemical stability of ondansetron hydrochloride with other drugs in admixtures via parenteral; a review. Farm Hosp. [online]. 2017, vol.41, n.5, pp.625-629. ISSN 2171-8695. https://dx.doi.org/10.7399/fh.10787.
Objective:
This review was prepared to offer the most complete information about the use of ondansetron in parenteral admixtures with other drugs.
Method:
The search was done from September 2016 to April 2017 by using electronic databases Stabilis® and Micromedex® solutions, Medline/PubMed and Scholar Google searching publications about ondansetron stability in parenteral infusion when is administered by itself or with other medication.
Results:
49 studies are included with a total of 53 drugs. 15 drugs were found compatible administered with ondansetron in a clinical routine concentration range in intravenous administration. Also, four ternary blends were found compatible and another one was incompatible. Otherwise, 38 drugs were found incompatible.
Conclusions:
Compatibility of ondansetron offers a broad number of options to be used to avoid nausea and vomiting symptoms in patients with other concomitant medication.
Keywords : Ondansetron; Chemical stability; Oncology; Nausea; Palliative medicine.
