Abstract

ARMERO, P. et al. Genetic foundations of pain. Rev. Soc. Esp. Dolor [online]. 2004, vol.11, n.7, pp.64-71. ISSN 1134-8046.

Perception of pain is a complex process which implies multiple biochemical pathways together with unknown processes of cortical integration. The existence of individual differences in the response to painful stimuli suggests that genetic factors can be involved in its modulation. Two different experimental approaches have been developed to study the implication of genotype in the response to pain: linkage studies and the association studies. Up to now linkage studies have allowed the association of TRKA gene mutations with the syndrome of congenital insensitivity to pain with anhidrosis (CIPA) and CACNL1A4 gene mutations with the familial hemiplegic migraine (FHM). Few association studies have been performed until now, and have been focused on the study of patients with migraine. Here we review the studies carried out up to now in different laboratories and suggest new perspectives for the future.

Keywords : Pain; Genes; Polymorphism; Mutation.

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