Abstract

GARCIA-HAREL, P. et al. Parecoxib versus ketorolac for the management of moderate postoperative acute pain. Rev. Soc. Esp. Dolor [online]. 2005, vol.12, n.6, pp.326-332. ISSN 1134-8046.

Introduction and objectives: Parecoxib is a pro-drug that after being injected into the body, it is rapidly converted into the active drug valdecoxib, an injectable selective inhibitor of cyclooxygenase 2 (COX-2). Our aim was to determine its effectiveness for the management of moderate postoperative pain. Material and methods: A prospective randomized study was conducted on a total of 96 patients undergoing: appendectomies, oophorectomies, hernioplasties and hip fractures between January and February 2004. One group received parecoxib 40 mg IV each 12 hours (group P) and the other one received ketorolac 30 mg IV each 8 hours (group K). Rescue analgesia was paracetamol 1 g IV each 6 hours. An analogical visual scale was used 30 minutes after admittance to the postoperative recovery unit, and after 2, 24 and 48 hours. Results: Pain was assessed through the VAS scale, with no differences found between groups. The need of rescue analgesia on the first day was 83.3% (40/48) in group K, versus 66.7% (32/48) in group P; (p = 0.059). On the second day, the demand of additional analgesia decreased. The need of rescue analgesia was greater among patients undergoing traumatological surgery. Patients that received parecoxib showed a greater percentage of satisfaction, this difference being significant. Conclusions: Pain management was similar in both groups. However, the analgesic patterns showed limitations in the management of pain, since the VAS score and the degree of satisfaction during the first hours can be improved. Considering the effectiveness of rescue therapy with paracetamol, parecoxib combined with paracetamol may be an useful combination for postoperative analgesic management.

Keywords : Postoperative analgesia; Parecoxib; Ketorolac; Paracetamol.

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