Abstract

GARCIA-PARTIDA, JA; BERROCOSO, E  and  MICO, JA. Experimental models for pain evaluation in osteoarthritis. Rev. Soc. Esp. Dolor [online]. 2021, vol.28, suppl.1, pp.18-30.  Epub Mar 08, 2021. ISSN 1134-8046.  https://dx.doi.org/10.20986/resed.2021.3872/2020.

Osteoarthritis (OA) is one of the main pathologies associated with chronic pain, and despite decades of study many key aspects of its pathophysiology are still unknown, which contributes to continuing to investigate therapeutic options capable of effectively and safely controlling pain. The use of experimental models of OA continues to be one of the most useful alternatives for understanding both the etiopathogenesis of OA and for the development of possible biomarkers and treatments. Despite the usefulness of experimental models in the advancement of knowledge of OA, there is no single model or technical procedure that allows us to study in it the great variety of structural and symptomatic changes that occur in the patient throughout his illness. However, today we have models and techniques for pain assessment that allow us to understand the mechanisms underlying OA as well as to understand and explore new therapeutic opportunities for its more effective and safe control.

Keywords : Pain; osteoarthritis; experimental models.

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