Abstract

TORNERO CRESPO, MM  and  MONTERO MATAMALA, A. Review of the pharmacological treatment of osteoarthritis pain with paracetamol, non-steroid anti-inflammatory (NSAIDSS) and selective cyclooxygenase-2 inhibitors (COXIB). Rev. Soc. Esp. Dolor [online]. 2021, vol.28, suppl.1, pp.43-48.  Epub Mar 08, 2021. ISSN 1134-8046.  https://dx.doi.org/10.20986/resed.2021.3864/2020.

In this monograph, a review of all aspects related to osteoarthritis is carried out in order to offer the patient with osteoarthritis the most optimal management in light of the bibliography available at the time of writing.

In this specific article, we made a bibliographic review of the pharmacological treatment of osteoarthritis with paracetamol, classical non-steroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase type 2 inhibitors (COXIBS).

We update the aspects that interest us most from a clinical point of view: efficacy, safety, comparison within these options and with the rest of the alternatives (interventional or other pharmacological) for being able to decide the patient profiles in which this type is indicated of pharmacological options, the evolutionary moment of the disease or even the maintenance time of this type of drug.

For reaching our objective, we have carried out a bibliographic review of the studies evaluating the effect of these analgesic drugs in osteoarthritis with an electronic search using Google Scholar, Medline/PubMed and the Cochrane database of systematic reviews to compile the available literature between the years 2000 and 2020.

Keywords : Osteoarthritis; paracetamol; COXIB; NSAIDS; nonsteroidal anti-inflammatory drugs; topical therapies; cyclooxygenase-2 inhibitors..

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