Abstract

ORTS-JORQUERA, B; MURIEL-SERRANO, J  and  PEIRO-PEIRO, AM. Pharmacogenetics in analgesic response: towards a sex-differences personalized medicine. Rev. Soc. Esp. Dolor [online]. 2023, vol.30, n.2, pp.115-124.  Epub Feb 05, 2024. ISSN 1134-8046.  https://dx.doi.org/10.20986/resed.2023.4042/2022.

Chronic pain is a silent epidemic, affecting 1 in 5 adults in Europe. This fact coexists with the abuse of analgesic drugs by some patients, a circumstance that is limiting their prescription in chronic non-cancer pain. The challenge would be to be able to select the people who, a priori, would have a better analgesic response based on a series of intrinsic conditions. This review analyzes the differences based on sex and the presence of certain variants in the genes that encode the mu opioid receptor (OPRM1), the cytochrome metabolizing enzyme CYP2D6 and the catechol-O-methyltransferase (COMT) that degrades catecholamines. The objective is to provide potentially explanatory elements that can guide the clinical professional in the selection of a more personalized analgesia.

Keywords : Chronic pain; pharmacogenetics; OPRM1; CYP2D6; sex-differences.

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