Abstract

PIPPA, R.  and  ODERO, M.D.. Importance of genetics in acute myeloid leukemia. Anales Sis San Navarra [online]. 2014, vol.37, n.3, pp.429-434. ISSN 1137-6627.  https://dx.doi.org/10.4321/S1137-66272014000300011.

Acute myeloid leukemia (AML) comprises a biologically and clinically heterogeneous group of aggressive disorders that occur as a consequence of a wide variety of genetic and epigenetic abnormalities in hematopoietic progenitors. Despite significant advances in the understanding of the biology of AML, most patients will die from relapsed disease. Whole-genome studies have identified novel recurrent gene mutations with prognostic impact in AML; furthermore, it is likely that in the near future genome-wide sequencing will become a routine for newly diagnosed patients with AML. Therefore, future clinical trials should aim to identify genetically defined high-risk patients, and further research is necessary to identify effective agents and develop new individualized therapeutic strategies for the treatment of this deadly disease.

Keywords : Acute myeloid leukemia; Genetic marker; Mutation; Whole-genome sequencing; Prognosis.

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