Abstract

ARIAS-DE LA VEGA, Fernando et al. Paraneoplastic hemolytic anemia associated with prostate cancer. A case report. Anales Sis San Navarra [online]. 2022, vol.45, n.3, e1023.  Epub Apr 24, 2023. ISSN 1137-6627.  https://dx.doi.org/10.23938/assn.1023.

Paraneoplastic syndromes are a group of tumor-related symptoms not directly attributable to tumors or metastasis. Symptoms are caused by secretion of substances by the tumor or the production of antibodies from immune cross-reactivity between tumor and normal tissues. Among hematological paraneoplastic syndromes, cancer-associated hemolytic anemias associated are rare, particularly in solid tumors.

We present the case of a patient with localized bladder (high-grade infiltrating papillary carcinoma pT1) and prostate (Gleason 7) cancer who developed warm antibody autoimmune hemolytic anemia during radiation therapy for prostate cancer. It was resolved with prednisone (1 mg/Kg/day, tapering schedule). To the best of our knowledge, this is the first time an autoimmune hemolytic anemia is described in the literature as a paraneoplastic syndrome in such early stages of tumor disease.

Keywords : Prostate cancer; Paraneoplastic; Anemia; Autoimmune; Hemolysis.

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