Abstract

CALSINA-GOMIS, Gloria  and  SERRANO-GRANGER, Jorge. Are there any differences between different concentrations of clorhexidine?: Comparison of mouthrinses. RCOE [online]. 2005, vol.10, n.4, pp.457-464. ISSN 1138-123X.

Mouthrinses containing chlorhexidine appear to be the most effective chemical agents in plaque control, with most of them being of 0.12% and 0.20% concentrations. Plaque inhibition by chlorhexidine is dose-dependent, which means that comparable effects can be obtained with a smaller volume of a mouthrinse with a higher concentration. The optimum dose of chlorhexidine delivered by mouthrinse, which balances efficacy against local side effects, is considered to be around 20 mg twice a day. Better compliance and less tooth staining with shorter rinsing time (30 seconds) is suggested. Chlorhexidine at usual concentrations of 0.12% and 0.20% produce side-effects such as extrinsic tooth staining leading to the search of different formulations: chlorhexidine at lower concentrations (0.05%) combined with the incorporation of other active agents to the formulation such as sodium fluoride (0.05%), cetylpyridinium chloride (0.05%) and triclosan is being studied. However, it seems that these lower concentrations are not exempt from the staining effects. Furthermore, there are very few long-term studies using these concentrations, so their long-tem effect regarding efficacy and side effects is not known.

Keywords : Chlorhexidine; Mouthrinse; Concentration.

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