Abstract

SANCHEZ, Magda et al. Comparison of "mid-dilution" haemodiafiltration with pre- and post-dilution haemodiafiltration. Rev Soc Esp Enferm Nefrol [online]. 2009, vol.12, n.1, pp.6-10. ISSN 1139-1375.

Various alternative forms of haemodiafiltration are possible depending on when the reinfusion liquid is incorporated: pre-dilution (before the dialyser), postdilution (after the dialyser) and mixed (pre- and post-dilution). An alternative to the latter is a dialyser designed for mid-dilution, where the blood passes through a membrane of central fibres and returns, in the opposite direction, through peripheral fibres. The reinfusion liquid is incorporated in half of the two sections of the dialyser. Thus, in the first section post-dilution haemodiafiltration takes place, and in the second section, pre-dilution haemodiafiltration. The aim of this study was to compare the forms of mid-dilution infusion with pre- and post-dilution, evaluating the removal of various molecules with different molecular weight. Each patient underwent three dialysis sessions, using a different technique each time, respecting the characteristics of the dialysis except for the infusion volume. Mid-dilution on-line haemodiafiltration seems to a be a good alternative that permits high convective volumes with a greater purification of β2-microglobulin, prolactin, myoglobin and retinol binding protein compared to post-dilution haemodiafiltration, and more marked compared to pre-dilution haemodiafiltration.

Keywords : mid-dilution haemodiafiltration; on-line haemodiafiltration; dialytic efficacy.

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