Abstract

BUNUEL ALVAREZ, J. C.. There is no evidence to recommend azithromycin to prevent recurrent wheezing after bronchiolitis. Rev Pediatr Aten Primaria [online]. 2015, vol.17, n.68, pp.369-372. ISSN 1139-7632.  https://dx.doi.org/10.4321/S1139-76322015000500016.

Review and assessment of a selected paper. Authors' conclusions: azithromycin decreased interleukin-8 nasopharyngeal concentration during the study period, and delayed the onset of a subsequent third episode of recurrent wheezing during the monitoring period. Reviewers' commentary: the results of this trial are not sufficient to recommend indiscriminate use of azithromycin for the treatment of acute bronchiolitis during admission, nor to prevent possible further episodes of recurrent wheezing. If azithromycin actually had any clinically important effect on acute bronchiolitis and its recurrences, it should be demonstrated in a clinical trial specifically designed for this purpose, since the results of a pilot trial cannot be taken as a basis for changes in everyday clinical practice.

Keywords : Bronchiolitis; Azithromycin.

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