Abstract

PONCE BRAVO, Santa; LEDESMA MONTES, Constantino; LOPEZ BECERRIL, Uriel  and  MORALES SANCHEZ, Israel. Myoepithelial cells are the main component in pleomorphic adenomas?. Med. oral patol. oral cir.bucal (Internet) [online]. 2007, vol.12, n.2, pp.110-115. ISSN 1698-6946.

Objective: The aim of this study was to quantify by immunohistochemistry the number of myoepithelial cells (MyECs) in pleomorphic adenomas (PAs). Material and methods: We retrieved the paraffin cubes of 27 PAs, new slides were done and they were stained with anti-S100 protein antibody. The amount of S-100 protein positive cells was quantified, their morphology was recorded and comparison among MyEC number with age, gender and involved gland were also done. Results: With S-100 protein, MyECs in normal salivary gland tissue were seen surrounding the ductual structures only. In the analysed PAs a mean of 27.4% of the neoplastic cells were positive to the antibody. With the exception of one PA, in all the analysed cases the plasmacytoid cells were the most commonly identified cells (48,6%). Conclusions: Results of this study suggest that MyECs do not constitute the main cellular component of the neoplastic compartment in PAs and corroborate the previously reported evidence by different au-thors, who studying the PAs suggested that MyECs does not comprise the main cellular neoplastic component of these entities.

Keywords : Pleomorphic adenomas; salivary gland tumors; myoepithelial cells; S-100 protein.

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