Introduction:

Since its endemic origin in India, the Asian cholera-morbidity overwhelmed the world in its first pandemic during the third decade of the XIX century, by then the etiological and therapeutic ignorance was total.

Main objective:

Investigating the scientific position, the interest is focused on the theoretical assumptions from which the great unknown of cholera was faced during his first visit to Spain in 1833 and 1834.

Methodology:

A historical study structured in a series of operations aimed at analyzing the publications of doctors who lived with and treated the disease. The search was carried out in the catalog of the Digital Hemeroteca of the National Library (HDBN) of Spain.

Results and Discussion:

Based on inclusion and exclusion criteria, 12 monographs were chosen that show the pathogenic theories, symptoms, prognosis, preventive measures, therapy and care.

Conclusions:

Within the controversy between contagionists-anticontagionists, and after living with the disease, each of them write their experience.