Abstract

CARRILLO DE ALBORNOZ SAINZ, A.; GARCIA KASS, A.  and  BASCONES MARTINEZ, A.. The role of IL-6 and TNF-a in periodontal disease. Avances en Periodoncia [online]. 2006, vol.18, n.2, pp.83-89. ISSN 2340-3209.

Periodontal disease is iniciated by several pathogens which induce an inflammatory cascade which stimulates the tisular destruction mediated by the host. Many inflammatory mediators are involved in this process. Amongst them we can remark IL-6 and TNF-a. IL-6 is a pleiotropic citokine of complex biological activity, which principal function linked to periodontitis is the induction of osseous resorption. TNF-a is a proinflammatory citokine which main function is the recruitment and stimulation of neutrophils and monocytes. Its role upon periodontitis is diverse. It gives rise to inflammation, as well as osseous resorption and connective tissue destruction, and limitates the reparative potential of periodontium.

Keywords : IL-6; TNF-a; citokines; periodontitis.

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