Abstract

ARDILA MEDINA, C.M.. Potential effect of simvastatin in tissue regeneration. Avances en Periodoncia [online]. 2013, vol.25, n.1, pp.11-16. ISSN 2340-3209.

Simvastatin (SIM) is a lactone which is used to lower cholesterol. Studies in vitro and in animals have been shown to induce osteoblastic activity and leads to bone formation by increasing the expression of bone morphogenetic protein-2. The SIM also promote bone formation, suppresses the synthesis of mevalonate and pyrophosphates, which in turn inhibit the formation and activity of osteoclasts. The SIM is a potential therapeutic agent for patients with osteoporosis and may facilitate the development of therapeutic strategies designed to repair local bone abnormalities such as periodontal lesions, periapical lesions, alveolar ridge defects and bone defects associated with implants. It was also indicated as the active ingredient to accelerate cell differentiation in human dental pulp. However, controlled clinical trials are required further corroborating the results of investigations in experimental animal models.

Keywords : Simvastatin; tissue regeneration; cell differentiation.

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