Abstract

ROMERO-SANCHEZ, C. et al. Serum amiloyd A protein as a systemic inflammatory marker in patients with periodontal disease. Avances en Periodoncia [online]. 2013, vol.25, n.1, pp.49-57. ISSN 2340-3209.

The acute phase response is the immediate host inflammatory reaction, which counteract challenges such as tissue injury, infection and trauma. The acute phase reactants that have receive most attention are: CRP, serum P component, serum amyloid protein and alpha 1 Acid glycoprotein. In past decades it has been established that acute phase proteins appear not only in severe disease processes but also in severe and chronic conditions. The AAS is the main component of secondary amyloid plaques deposited in major organs as a result of chronic inflammatory disease. The family of SAA contains a number of different expressed apolipoproteins, which are synthesized by the liver. Increased SAA is a marker of systemic acute inflammatory diseases and chronic diseases affecting the composition and function of HDL. It was show that therapeutic intervention in periodontitis diseases decreases inflammation and reduces SAA and can therefore significantly reduce the risk of CVD. Besides it is possible that patients with periodontitis, who have an increase in the levels of CRP and SAA represent a specific subgroup in terms of risk for atherosclerosis and cardiovascular illness in comparison to patients with periodontitis, whose plasma levels of SAA are normal, establishing thus a direct relation between periodontal disease and the levels SAA.

Keywords : Periodontitis; serum amyloid; inflammation; periodontal disease.

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