Abstract

FERRER-MACHIN, A; GARCIA-GARCIA, PM; PLASENCIA-GARCIA, I  and  MERINO-ALONSO, J. Urea as a therapeutic alternative to tolvaptan in the treatment of hyponatremia: case report. Rev. OFIL·ILAPHAR [online]. 2020, vol.30, n.4, pp.339-341.  Epub May 25, 2021. ISSN 1699-714X.  https://dx.doi.org/10.4321/s1699-714x2020000400014.

Patients with inadequate antidiuretic hormone secretion (SIADH) are prone to hyponatremia. Tolvaptan is indicated in adults for the treatment of hyponatremia secondary to SIADH. However, urea is proposed as a good therapeutic option for increasing sodium levels. In this document we report the case of a patient with hyponatremia associated with SIAH who is treated with tolvaptan, achieving a highly variable plasma sodium concentration. It seems that urea can contribute to a better control of sodium levels with a slower, progressive and stable rise, providing greater safety to our patient and also achieving cost reduction.

Keywords : Hyponatremia; inadequate antidiuretic hormone secretion; urea.

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