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Revista de la OFIL
On-line version ISSN 1699-714XPrint version ISSN 1131-9429
Abstract
SAEZ-TORRES DE VICENTE, M; LOPEZ-SANTAMARIA DONOSO, J and AUMENTE RUBIO, MD. Vancomycin dosage in patients undergoing intermittent dialysis. Preparation of an initial dosage protocol. Rev. OFIL·ILAPHAR [online]. 2021, vol.31, n.1, pp.28-31. Epub June 07, 2021. ISSN 1699-714X. https://dx.doi.org/10.4321/s1699-714x2021000100007.
Objective:
To review the initial dosage of vancomycin in patients on intermittent hemodialysis, to establish a dosing protocol that allows reaching an optimal pre-dialysis concentration (15-20 µg/ml) after loading dose and first maintenance dose.
Method:
Observational, retrospective, unicentric study in which all hemodialysis (HD) patients who received vancomycin, during the last hour of the session, between September 2010 and January 2018, were included.
Results:
87 patients were included, considering the value optimal Cmin=15-20 µg/ml, only 12.6% of the patients after the loading dose and 18.4% after the maintenance dose reached the reference value.
Conclusions:
The initial empirical regimen of vancomycin was insufficient in most patients to reach optimal concentrations from the beginning of treatment, so a new dosing protocol adapted to the patient's weight is proposed.
Keywords : Vancomycin; hemodialysis; optimal concentration; dosage; protocol.
