SciELO - Scientific Electronic Library Online

 
vol.32 issue4Antidigoxin antibodies and renal failure: rebound toxicity. A case reportManagement of high doses of methotrexate in a case of acute lymphoblastic leukemia author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google

Share


Revista de la OFIL

On-line version ISSN 1699-714XPrint version ISSN 1131-9429

Abstract

DE LA CALLE-RIAGUAS, B; CASAMAYOR-LAZAR, B; GOMEZ-ESPINOSA, P  and  BERROCAL-JAVATO, MA. COVID-19 in a patient with spinal muscular atrophy: a case report. Rev. OFIL·ILAPHAR [online]. 2022, vol.32, n.4, pp.397-399.  Epub Oct 23, 2023. ISSN 1699-714X.  https://dx.doi.org/10.4321/s1699-714x20220004000014.

Spinal muscular atrophy (SMA) is a rare autosomal recessive disease with an overall incidence of 4 to 10 cases per 100,000 newborns. It is caused by progressive degeneration of the anterior horn cells in the spinal cord, which cause weakness and muscle atrophy, potentially leading to dependence and early death1,2. There is currently no curative treatment for SMA and the therapeutic interventions available are based on motor rehabilitation measures and symptomatic treatment3,4. Nusinersen has been the first drug approved for this disease, allowing the acquisition and development of motor functions increasing the overall survival of these patients4. We present the case of a patient who, five days after birth, has shown SMA clinical symptoms, doses, until the control test performed by protocol prior to administration of the eighth dose, positive PCR for SARS-CoV-2 was detected and isolation was decided. However, two days later, he went to the emergency room for acute respiratory failure, requiring hospital admission where it was decided to continue administering nusinersen, which has proven to be beneficial in the underlying pathology.

Keywords : Spinal muscular atrophy; nusinersen; COVID-19; SARS-CoV-2; methylprednisolone.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )