Abstract

KANTEREWICZ, E. et al. Risk of fracture in the FRODOS cohort: comparative study of the application of the Spanish, French, British and Swedish FRAX^® models. Rev Osteoporos Metab Miner [online]. 2014, vol.6, n.1, pp.14-19. ISSN 2173-2345.  https://dx.doi.org/10.4321/S1889-836X2014000100004.

Background and objectives: Studies on the validation of FRAX^® in Spain show an underestimation of the risk of principal osteoporotic fractures (POFs) and more accurate predictions for femoral fractures (FF). It has been suggested that this algorithm may be improved with more specific data on the epidemiology of these fractures in Spain. The objectives of this work were to describe the baseline risk of fractures according to the Spanish FRAX^® model in the participants of the FRODOS cohort, and to compare these data with the application of other European models of FRAX^® in the same cohort. Methods: Observational study in a population cohort of 2,968 postmenopausal women (59-70 years of age). The online desktop version of FRAX^® was used  for multiple data entries to calculate the risk of POFs and FFs at 10 years using the Spanish, French, British and Swedish models in the same cohort. Results: The lowest risk corresponded to the Spanish model: FF: 1.22% (36 expected fractures) and POF: 5.28% (n=197), while the highest risk was for the Swedish model: FF: 3.15% and POF 13.51% (n=401). The models for France and the United Kingdom had intermediate values. Conclusion: In a Spanish cohort of 2,968 postmenopausal women the percentage risk of expected fractures at 10 years increased following a south-north latitude gradient when different European FRAX^® models were applied. The results for the incidence of fractures on the FRODOS cohort predicted for the coming years will confirm, or not, the usefulness of this analysis.

Keywords : FRAX; osteoporosis; risk of fracture.

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