Abstract

GONZALEZ-ROZAS, M.  and  PEREZ CASTRILLON, J.L.. Endocrine regulation of energy metabolism by bone. Rev Osteoporos Metab Miner [online]. 2014, vol.6, n.2, pp.57-62. ISSN 2173-2345.  https://dx.doi.org/10.4321/S1889-836X2014000200005.

The classical functions of bone are the maintenance of phosphorus-calcium homeostasis, damage repair, as well its structural function which allows locomotion and protects the vital organs. The recent discovery of new functions for bone in the regulation of energy metabolism suggest that bone may be an endocrine organ. In the last decade, different genetic and molecular studies carried out in mice have determined that osteocalcin increases the secretion of insulin, and sensitivity to it, by increasing the secretion of adiponectin, stimulates the proliferation and the better functioning of the beta cells, promotes the reduction of fatty mass and an increase in the consumption of energy. These findings demonstrate the existence of a reciprocal regulation between bone and energy metabolism, mediated by osteocalcin. The recognition of the metabolic role of osteocalcin is a significant discovery in the field of osteology and endocrinology, bringing the possibility of new therapies in the treatment and prevention of metabolic diseases such as diabetes mellitus, sarcopenia, obesity and osteoporosis.

Keywords : osteocalcin; bone; endocrine organ; energy metabolism; insulin; diabetes mellitus; obesity.

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