Abstract

CANTELLANO-SANCHEZ, Perla Marisol; ORTEGA-MELENDEZ, Alejandra Isabel; VELAZQUEZ-CRUZ, Rafael  and  JIMENEZ-ORTEGA, Rogelio Frank. Function of sex hormones in bone homeostasis and their role in the development of male osteoporosis: a narrative review. Rev Osteoporos Metab Miner [online]. 2023, vol.15, n.4, pp.144-153.  Epub Feb 19, 2024. ISSN 2173-2345.  https://dx.doi.org/10.20960/revosteoporosmetabminer.00024.

Bone is a dynamic tissue that undergoes constant adaptation throughout the life of vertebrates to achieve size, shape, preserve the structural integrity of the skeleton, and regulate mineral homeostasis. Bone growth during childhood is crucial to achieve height and resistance to fractures later in life. Sex hormones play a key role in bone remodeling in men and women alike, and changes to hormonal profiles can trigger bone metabolism-related diseases. In women, estrogen deficiency during menopause is one of the leading causes of osteoporosis, while in men, androgens can have an impact on bone health by binding directly to androgen receptors or indirectly to estrogen receptors.

This review explores the role and effects of sex hormones on bone metabolism, the signaling pathways involved, and the effects that can trigger diseases such as osteoporosis.

Keywords : Male osteoporosis; Androgens; Estrogens; Testosterone.

        · abstract in Spanish     · text in English | Spanish     · Spanish ( pdf )