Abstract

KESERVANI, Raj K.; SHARMA, Anil K.  and  JAROULIYA, Urmila. Protein and Peptide in Drug Targeting and its Therapeutic Approach. Ars Pharm [online]. 2015, vol.56, n.3, pp.165-177. ISSN 2340-9894.  https://dx.doi.org/10.4321/S2340-98942015000300006.

Aim: The main aim of this review article is to provide information like advantages of protein and peptides via different routes of drug administration, targeted to a particular site and its implication in drug delivery system. Methods: To that aim, from the web sites of PubMed, HCAplus, Thomson, and Registry were used as the main sources to perform the search for the most significant research articles published on the subject. The information was then carefully analyzed, highlighting the most important results in the development of protein and peptide drug targeting as well as its therapeutic activity. Results: In recent years many researchers use protein and peptide as a target site of drug by a different delivery system. Proteins and peptides are used as specific and effective therapeutic agents, due to instability and side effects their use is complicated. Protein kinases are important regulators of most, if not all, biological processes. Abnormal activity of proteins and peptides has been implicated in many human diseases, such as diabetes, cancer and neurodegenerative disorders. Conclusions: It is concluded that the protein and peptide were used in drug targeting to specific site and also used in different diseased states like cancer, diabetes, immunomodulating, neurodegenerative effects and antimicrobial activity.

Keywords : Protein; Peptide; Controlled release; Bioerodible polymer.

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