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Ars Pharmaceutica (Internet)
On-line version ISSN 2340-9894
Abstract
SCHERER SANTOS, Júlia et al. Screening of avocado oil nanoformulations intended to skin delivery. Ars Pharm [online]. 2021, vol.62, n.1, pp.66-74. Epub Mar 29, 2021. ISSN 2340-9894. https://dx.doi.org/10.30827/ars.v62i1.15486.
Introduction:
vegetable ingredients are increasingly common in skin products. Avocado oil is an ingredient of natural sources with various properties on the skin. In this work, crude avocado oil-loaded nanocapsules were evaluated regarding its physicochemical stability to obtain a formulation of skin delivery with adequate quality: suitable physicochemical stability, with low polydispersity and with a pH suitable for cutaneous application.
Method:
nanoparticle formulations with components variation were evaluated for 2 months. Nanoparticle formulation considered the most stable was further evaluated for 6 months. Furthermore, the oxidative stability of crude avocado oil loaded in nanocapsules and standard avocado oil was also performed to detect any sign of oil oxidation.
Results:
all formulations had negative zeta potential after 2 months of storage. pH values of nanoparticles remained stable throughout the test. Formulation with the lowest content of ingredients exhibited the highest stability after 2 months of storage. Nanoencapsulated avocado oil and crude avocado oil showed no evidence of oxidation.
Conclusions:
Aqueous dispersions with the lowest content of ingredients presented the best physicochemical stability. Therefore, we have demonstrated preliminary the feasibility of developing avocado-oil loaded nanocapsules.
Keywords : avocado oil; aqueous dispersions; nanoparticles; vegetable oil..