Abstract

BONILLA-PLAZA, Jaime Andrés et al. Lower back pain after iodine-131-6-β-iodomethyl-19-norcholesterol injection: a case report. Ars Pharm [online]. 2022, vol.63, n.2, pp.173-177.  Epub Apr 25, 2022. ISSN 2340-9894.  https://dx.doi.org/10.30827/ars.v63i2.23505.

The [131I]Iodine-6-β-iodomethyl-19-norcholesterol ([131I]Norcholesterol; NP-59), is indicated in the diagnosis of the functional state of adrenal cortical tissue, in the detection of functional tissue in hyperadrenocorticalism as well as in primary aldosteronism. We present the case of a 54-year-old woman, referred for evaluation of suspected aldosteronism, and who immediately after intravenous administration of [131I]Norcholesterol suffered a strong adverse drug reaction, with dizziness, flushing, increased blood pressure, chest tightness, low back pain and erythematous rash up to 9 days after injection. Symptoms resolved satisfactorily after administration of antihistamines and corticosteroids. This reaction was suspected to be related to the administration of [131I]Norcholesterol caused by a type I allergic reaction.

Keywords : NP-59; adverse drug reaction; pharmacovigilance.

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